Aging and chronic disease development are multifactorial processes involving the cumulative effects of metabolic distress, inflammation, oxidative stress and mitochondrial dynamics. Recently, variations in the gut microbiota have been associated with age-related phenotypes and probiotics have shown promise in managing chronic disease progression. In this study, novel probiotic and synbiotic formulations are shown to combinatorially extend longevity in male Drosophila melanogaster through mechanisms of gut-brain-axis communication with implications in chronic disease management. Both the probiotic and synbiotic formulations rescued markers of metabolic stress by managing insulin resistance and energy regulatory pathways. Both formulations also ameliorated elevations in inflammation, oxidative stress and the loss of mitochondrial complex integrity. In almost all the measured pathways, the synbiotic formulation has a more robust impact than its individual components insinuating its combinatorial effect. The concomitant action of the gut microbiota on each of the key risk factors of aging and makes it a powerful therapeutic tool against neurodegeneration, diabetes, obesity, cardiovascular disease and other age-related chronic diseases.
Moreover, since both thoughts and perceptions are mental in essence, this line of reasoning points to mind as the primary substrate of nature, the discernible states of which constitute information.
There was a moment at the river with my mother long ago, when I asked her why we pray. She told me that prayer was not begging, or asking for things, but an expression of gratitude for the way things are. She looked at me, and behind her the river was not rushing. There were so many spirals in the current of the river, and many undertows.
She saw what I was staring at. “That is your power too,” she said. “The undertow can drown people.” I knew she was pointing to the chaos of what we cannot see, and that the undercurrent—the chaos and conflict beneath every surface—is necessary.
At times philosophers are like magicians whose whole world of magic is bound within evasion and trickery, seeking to keep your mind occupied by the bells-and-whistles of distraction and stage props while the real work goes on elsewhere and in plain sight. The philosopher’s old enemy was the rhetorician, the Sophist, who could use the figures of intellect and speech to cover over the truth in a veil of pure illusion and make it seem by way of metaphor and rhetorical flourish the very thing itself. But the philosopher is himself caught in the trap of self-deception, believing that the very words he so uses under the scrutiny of careful persuasion and example have the power to awaken truth from its hiding places while all the time as Nietzsche reminds us: “Even great spirits have only their five-fingers’ breadth of experience – just beyond it their thinking ceases and their endless empty space and stupidity begins.”